FOR IMMEDIATE RELEASE
Orthomolecular Medicine News Service, June 12, 2023

Drs. Wilfrid & Evan Shute Cured Thousands with Vitamin E
And it all began over 70 years ago

by Andrew W. Saul, Editor

OMNS (June 12, 2023) The first course I ever taught was entitled "Forgotten Research in Medicine." That was in 1976. Even by that time, there had been a strikingly large number of impeccably qualified researchers and physicians who had left drug-and-cut medicine behind in favor of a naturopathic approach. I had seen so much well-documented evidence for the safety and effectiveness of therapeutic nutrition against major chronic diseases that I figured it must presently be self-evident to everybody. Surely, I thought, it could only be a matter of time (say twenty years at most) until all doctors shifted to natural healing, because word would spread like wildfire and all their patients would demand it of them.

I'd read a variety of articles documenting an incredibly bitter controversy which raged throughout the 1950's over the use of vitamin E (d-alpha tocopherol) for cardiovascular disease. Drs. Wilfrid and Evan Shute were at the center of this storm, which encircled their work in Ontario, Canada. They were among the very first medical doctors to clinically employ large doses of the vitamin in place of conventional drug therapy. Almost all of the positive articles I saw were based on case histories and came from the popular press. Almost all of the criticism seemed to come from the medical press, which seemed singularly resistant to even try the Shute's approach, let alone endorse it. Yet, somehow, their unwillingness to test the Shute's high-dose, natural vitamin E protocol did not seem to prevent them from dismissing it.

In the early 50's, Canada was a hotbed of leading-edge nutritional research. In Saskatchewan at about the same time, Dr. Abram Hoffer and Dr. Humphrey Osmond found that niacin was the best way to treat psychosis. The Shutes found that vitamin E was the best way to treat heart disease. One might think that the only possible professional response to such important discoveries would be grateful acceptance and widespread journal publication.

Just the opposite occurred.

https://www.seleneriverpress.com/images/pdfs/THE_FIGHT_OVER_VITAMIN_E_1954_Special_Reprint_4-54.pdf

For decades it has been said that pharmaceutical medicine has little to gain from a cheap vitamin cure that cannot be patented and exploited for high profit. Observers have also witnessed what happens to medical doctors that have defected to drugless healing: they gain many grateful patients, and lose a lot of research funding. Few pharmaceutical companies willingly contribute to the competition.

The Shutes saw early that such would be the case, and paid their own way. They created their own research foundation and treatment facility (the Shute Institute), created their own journal (the Summary), and in so doing, some would say, created their own trouble.

Oddly enough, in 1948 they actually advocated making vitamin E a prescription item.

Perhaps this is understandable, given the spectacular, wonder-drug-style patient recoveries that the Shutes had already seen by mid-century.

TWENTY YEARS OF IGNORED SHUTE VITAMIN E RESEARCH: A Timeline

1936: Vitamin E-rich wheat germ oil cures angina.

1940: Vitamin E suspected as preventive of fibroids and endometriosis, and curative of atherosclerosis.

1945: Vitamin E shown to cure hemorrhages in skin and mucous membranes, and to decrease the diabetic's need for insulin.

1946: Vitamin E greatly improves wound healing, including skin ulcers. Also demonstrated effective in cases of claudication, acute nephritis, thrombosis, cirrhosis and phlebitis. Vitamin E strengthens and regulates heartbeat.

1947: Vitamin E successfully used as therapy for gangrene, inflammation of blood vessels (Buerger's disease), retinitis and choroiditis.

1948: Vitamin E helps lupus erythematosus and shortness of breath.

1950: Vitamin E shown to be effective treatment for varicose veins, and in cases of severe body burns.

1954: The Shutes' medical textbook, Alpha Tocopherol in Cardiovascular Disease, is published.

1956: The Heart and Vitamin E is published.

It is not overly easy to see how such promise could be ignored for long. But it was. Dr. Evan Shute's frustration with an unnaturally stubborn medical profession comes starkly through the text in his book The Vitamin E Story:

"It was nearly impossible now for anyone who valued his future in Academe to espouse Vitamin E, prescribe it or advise its use. That would make a man a "quack" at once. This situation lasted for many years. In the United States, of course, the closure of the J.A.M.A. pages against us and tocopherol meant that it did not exist. It was either in the U.S. medical bible or it was nought. No amount of documentation could budge medical men from this stance. Literature in the positive was ignored and left unread. Individual doctors often said: "If it is as good as you say, we would all be using it." But nothing could induce them as persons of scientific background to make the simplest trial on a burn or coronary." (p 146)

The American Medical Association even refused to let the Shute's present their findings at national medical conventions. (p 148-9) In the early 1960's, the United States Post Office successfully prevented even the mailing of vitamin E. (p 166)

Linus Pauling wrote, in the book's 1985 forward:

"The failure of the medical establishment during the last forty years to recognize the value of Vitamin E in controlling heart disease is responsible for a tremendous amount of unnecessary suffering and for many early deaths. The interesting story of the efforts to suppress the Shute discoveries about Vitamin E illustrates the shocking bias of organized medicine against nutritional measures for achieving improved health." (vii)

O that things were truly better today, but they are not. Yes, the American public can and does buy vitamin E (even by mail) without a prescription. Still, I am unaware of any burn clinic using topical vitamin E as their primary treatment. I am yet to see "megadose vitamin E cures cardiovascular disease" commercials on TV. I have never seen a bottle of vitamin E in an intensive care unit. It has now been nearly 80 years since vitamin E was seen to greatly help diabetics and cardiovascular patients and only recently has medical research "discovered" a glimmer of the value of this vitamin. Yet for three-quarters of a century, vitamin E has been an available specific for intermittent claudication, angina, prevention of and recovery from heart attack, thrombophlebitis, and a wide variety of other serious conditions.

Aye, there's the rub.

Vitamin E is entirely too good for too many purposes. Consumer Reports trashed it in back in 1972, and often since. It didn't help matters that Evan Shute was "only" an obstetrician. (This obstetrician was, however, made a Fellow of the American Society of Angiology in 1969.) And today, vitamin E's very availability, and exceptional safety, seemingly render it unattractive for hospital use as the spectacular therapy that it is.

Tocopherol has been known and studied since the 1920's, generally in small quantities as a means to ensure a full-term pregnancy. Without the Shute brothers' high-dosage clinical work, especially in cardiology, no one at all would be megadosing with vitamin E today. We owe them our thanks, and our lives.

(This article appeared in the Journal of Orthomolecular Medicine, Vol. 17, No. 3, Third Quarter, 2002, pages 179-181 https://isom.ca/jom-archives/vol17-no3-2002/ and is reprinted with permission.)

A bibliography of the Shutes' principal written work is posted at http://www.doctoryourself.com/biblio_shute.html There is a whole lot for you to look at . . . for which I make no apology whatsoever. Cardiovascular disease remains our number one enemy, the biggest killer of men AND women.

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Editorial Review Board:

Albert G. B. Amoa, MB.Ch.B, Ph.D. (Ghana)
Seth Ayettey, M.B., Ch.B., Ph.D. (Ghana)
Ilyès Baghli, M.D. (Algeria)
Barry Breger, M.D. (Canada)
Ian Brighthope, MBBS, FACNEM (Australia)
Gilbert Henri Crussol, D.M.D. (Spain)
Carolyn Dean, M.D., N.D. (USA)
Ian Dettman, Ph.D. (Australia)
Susan R. Downs, M.D., M.P.H. (USA)
Ron Ehrlich, B.D.S. (Australia)
Hugo Galindo, M.D. (Colombia)
Gary S. Goldman, Ph.D. (USA)
William B. Grant, Ph.D. (USA)
Claus Hancke, MD, FACAM (Denmark)
Patrick Holford, BSc (United Kingdom)
Ron Hunninghake, M.D. (USA)
Bo H. Jonsson, M.D., Ph.D. (Sweden)
Dwight Kalita, Ph.D. (USA)
Felix I. D. Konotey-Ahulu, M.D., FRCP (Ghana)
Peter H. Lauda, M.D. (Austria)
Alan Lien, Ph.D. (Taiwan)
Homer Lim, M.D. (Philippines)
Stuart Lindsey, Pharm.D. (USA)
Pedro Gonzalez Lombana, M.D., Ph.D. (Colombia)
Victor A. Marcial-Vega, M.D. (Puerto Rico)
Juan Manuel Martinez, M.D. (Colombia)
Mignonne Mary, M.D. (USA)
Joseph Mercola, D.O. (USA)
Jorge R. Miranda-Massari, Pharm.D. (Puerto Rico)
Karin Munsterhjelm-Ahumada, M.D. (Finland)
Sarah Myhill, MB, BS (United Kingdom)
Tahar Naili, M.D. (Algeria)
Zhiyong Peng, M.D. (China)
Isabella Akyinbah Quakyi, Ph.D. (Ghana)
Selvam Rengasamy, MBBS, FRCOG (Malaysia)
Jeffrey A. Ruterbusch, D.O. (USA)
Gert E. Schuitemaker, Ph.D. (Netherlands)
Thomas N. Seyfried, Ph.D. (USA)
Han Ping Shi, M.D., Ph.D. (China)
T.E. Gabriel Stewart, M.B.B.CH. (Ireland)
Jagan Nathan Vamanan, M.D. (India)

Andrew W. Saul, Ph.D. (USA), Editor-In-Chief
Associate Editor: Robert G. Smith, Ph.D. (USA)
Editor, Japanese Edition: Atsuo Yanagisawa, M.D., Ph.D. (Japan)
Editor, Chinese Edition: Richard Cheng, M.D., Ph.D. (USA)
Editor, Norwegian Edition: Dag Viljen Poleszynski, Ph.D. (Norway)
Editor, Arabic Edition: Moustafa Kamel, R.Ph, P.G.C.M (Egypt)
Editor, Korean Edition: Hyoungjoo Shin, M.D. (South Korea)
Editor, Spanish Edition: Sonia Rita Rial, PhD (Argentina)
Editor, German Edition: Bernhard Welker, M.D. (Germany)
Associate Editor, German Edition: Gerhard Dachtler, M.Eng. (Germany)
Assistant Editor: Michael Passwater (USA)
Contributing Editor: Thomas E. Levy, M.D., J.D. (USA)
Contributing Editor: Damien Downing, M.B.B.S., M.R.S.B. (United Kingdom)
Contributing Editor: W. Todd Penberthy, Ph.D. (USA)
Contributing Editor: Ken Walker, M.D. (Canada)
Contributing Editor: Michael J. Gonzalez, N.M.D., Ph.D. (Puerto Rico)
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