Arthritis and Frequent Megadoses of Niacinamide (Vitamin B-3)

Arthritis and Vit B-3


by William Kaufman, M.D., Ph.D.
(Reprinted with the kind permission of Charlotte Kaufman)

The (more frequent) 250 mg dose of niacinamide is 40 to 50 % more effective in the treatment of arthritis than the (less frequent) 500 mg. dose. As an illustration, see the reprint of my Tom Spies Memorial Lecture: Niacinamide, a Most Neglected Vitamin. This illustrative case history begins on page 17 column 2 and continues on page 18 column 2.

Do not use hard gelatin capsules containing 250 mg niacinamide because they do not deliver niacinamide as efficiently as 250mg niacinamide in thin gelatin capsules in the treatment of joint dysfunction (arthritis).

In my paper in J. Amer Geriat. Society, 1955 3:927-936 I noted that niacinamide (alone or combined with other vitamins) in a thousand patient-years of use has caused no adverse side effects.

Some brands of niacinamide on the market today contains excipients that act as preservatives, probably meant to prolong shelf life. Some patients have severe adverse reactions to these preparations while most do not experience any ill effects.

Niacinamide has un-gated entrance to the central nervous system. It has a strong affinity for the central nervous system's benzodiazepine receptors and causes a pleasant calmative effect. In addition, it improves central nervous system function in the kinds of central nervous symptom impairments noted in my 1943 book, starting on page 3.

Please keep in mind niacinamide is a systemic therapeutic agent. It measurably improves joint mobility, muscle strength, decreases fatigability. It increases maximal muscle working capacity, reduces or completely eliminates arthritic joint pain. Niacinamide heals broken strands of DNA and improves many kinds of CNS functioning.

Some joints are so injured by the arthritic process that no amount of niacinamide therapy will cause improvement in joint mobility, but it takes three months of niacinamide therapy before you can conclude this, since some joints are slow to heal.

January 13,1998


Andrew W. Saul


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