||Schizophrenia and Psychosis Cured with
Nutrition Protocols and Case Histories of Abram Hoffer, MD, PhD
|Niacin Therapy for Schizophrenia and Psychosis
Megavitamin Therapy for Schizophrenia and Psychosis
by Abram Hoffer, M.D., Ph.D., F.R.C.P.S. (Can.)
The main difference is that formerly they were treated in inadequate hospitals, which provided shelter, food, nursing care and some medical care. Patients were protected from society and society was protected from the more violent aggressive psychotic patients. These patients had little personal freedom. Today, the modern mental hospital, which is the streets with their rundown hotels, nursing homes, foster homes and so on, provides tranquilizers for some, pays no attention to food, provides little shelter and provides no protection for patients and for society. But they do have much more freedom to be sick, to roam, to refuse medication, to prey upon others, to be preyed upon by others.
The end results are the same. Patients do not recover. The recovery rate today is certainly under 15% which is one-third of the recovery rate achieved in 1850 in England and in the USA in the Dorothea Lynde Dix hospital in the eastern part of the country. In my opinion, the street schizophrenics today are no better off than they were in 1950. They suffered tremendously then from psychiatric ignorance from this socially rejected disease, and they suffer today from psychiatric refusal to examine a much better treatment called orthomolecular therapy.
Modern drugs, primarily tranquilizers, are very helpful in ameliorating the symptoms of the disease, but by themselves they can not and do not lead to recovery. Psychiatric chemotherapy is equivalent to chemotherapy practiced by oncologists for most forms of cancer, they do little good and cause a lot of harm. Psychiatric chemotherapy leaves the unfortunate patients with a dismal choice: (1) to remain naturally psychotic without the benefit of these drugs in reducing suffering or, (2) suffering the iatrogenic organic disease, the tranquilizer psychosis.
Tranquilizers, no matter how helpful, create a major dilemma for patients and their psychiatrists. Given to patients, they help reduce the frequency and intensity of the symptoms, but given to normal people they make them sick. Under the communist regime in Russia, dissidents were locked up in mental hospitals and given tranquilizers. They were using their peculiar definition of mental illness, i.e. a person who disagreed with the system. These people were made psychotic by the tranquilizers. When patients are given the same drugs they begin to get better, their symptoms are alleviated to some degree, they are more comfortable and their families being to feel hopeful again that they will recover. But as they become better or more normal, they begin to respond to these drugs as if they were normal, i.e. they become sick.
The tranquilizer psychosis created by these
drugs includes psychiatric and physical symptoms. The psychiatric symptoms
are apathy, disinterest, poor concentration and memory problems so they
can not study and learn, personality deterioration, and inability to function
without supervision. On the physical side they develop tardive dyskinesia,
other types of neurological conditions, impotence, obesity, and skin problems.
Patients are no more fond of these latter symptoms than they are of their
natural schizophrenia, and many prefer to be psychotic rather than suffer
the ravages of this iatrogenic disease.
The importance of clinical diagnosis
I had decided to use the criteria, described so eloquently, by John Conolly, the superintendent of a mental hospital in England. He wrote the book Indications of Insanity. His definition was clear and elegant and is the best working definition of this condition. It was, he wrote, a disease of perception combined with an inability to tell whether these perceptual changes were real or not. I have used this definition since and I have found it most valuable. But unfortunately American psychiatry did not know about this definition and was raised on the definition described by E. Bleuler. Dr Bleuler's definition depended upon the presence or absence of thought disorder with very little emphasis given to perceptual changes. This still remains a basis for diagnosing except that a whole host of other factors have become operative, probably because it is so difficult to define accurately when thought disorder is present.
I also became aware many years ago that the diagnosis, like changes in clothing fashions, changed with the prevailing attitude toward this condition. Thus, in the early 1950's psychiatrists under the sway of psychoanalysis would not diagnose it unless there was evidence of latent homosexuality. I remember that at one clinical conference the psychiatrist presenting the case had diagnosed the patient schizophrenic and then added that he was homosexual. During the discussion I asked him whether in fact his patient had ever actually been homosexual. He replied that he had not, but he added he must be a latent homosexual since Freud had declared that this was the basis for paranoid schizophrenia.
When we were conducting the double blind experiments to test vitamin B-3 for treating schizophrenics I discovered that for a while we were no longer admitting any schizophrenic patients to the Munro Wing, the psychiatric ward of the General Hospital in Regina, Saskatchewan. However as the study ran for several years this dearth of patients that I could enter into the study was replaced by a shower of patients. I soon realized that there was enough resistance among the clinical staff to allowing their patients to be included in the study that they initially preferred to diagnose them depression or anxiety or psychopathy . But since these patients did not recover and relapsed after discharge, on readmission they were forced to make the correct diagnosis.
Another factor was the knowledge that schizophrenics did not respond to psychotherapy. Knowing this, psychiatrists, if they wanted to give psychotherapy and believed it had a chance would not diagnose their patients. I recall one patient, whom I interviewed after the resident had been treating her with psychotherapy for several months. As I was talking to her she kept on looking over my shoulder into the corner of the room at the ceiling. I asked her what was she looking at. She replied that her sister, who lived in Edmonton, was in the corner of the room at the ceiling level and she was looking at her. A few days after I informed the resident that she was hallucinating he changed the diagnosis and sent her to the closest mental hospital. Today psychiatrists know that psychotherapy alone is of little value. But they also know that drugs, although very helpful, do not really make schizophrenic patients normal. If, therefore, they have a patient that they really want to treat they will diagnose them as bipolar (manic-depressive), or depressed which most of them are, and can then use lithium or anti depressants. If they don't want to treat them, if they are especially difficult, or troublesome, or have a dislikable personality they will diagnose them as personality disorders. In any event the result is that patients who are schizophrenic, and who would respond to some treatment are ignored and banished to the modern mental hospital of our large cities, the city streets.
This case represents one such case.
Elizabeth came to see me December 18, 1995. Her family practitioner wrote in his letter referring her to me "She is a 28 year old with a long history of psychiatric illness with varied diagnosis including anorexia nervosa, borderline personality disorder, multiple personality disorder and these associated with suicide attempts and multiple hospitalizations". She had also been diagnosed depression.
About mid 1992 she began to suffer severe
headaches, about two to three times per month, unrelated to her periods,
often preceded by nausea and vomiting. She was given the usual variety
of headache medication without any response, including fiorinal, demerol,
gravol, tylenol, Imitrex by injection. Her general practitioner had reported
to the neurologist that she was working as a nurse's aid, was a good worker,
and hated missing work.
She was admitted again. In the meantime she had spent four months at a private facility for anorexics. She was committed with severe depression, auditory hallucinations and suicidal ideation. This admission she admitted she had been a victim of child sexual abuse, by her step father. She continued to hear voices but the psychiatrist in charge interpreted these as a projection of her own thoughts. He began to indulge in psychoanalytic speculations about the causes of her voices which he denied were hallucinations. For the first time the term personality disorder began to appear in her record. This is in striking contrast with the opinion of her general practitioner who had seen her as basically a normal, achieving person. She was diagnosed depression and placed on anti depressants.
April 7 to 20, 1995, she was assessed by psychologists, She reported hearing derogatory voices inside her head which had become louder in the past few years. She also heard voices from outside calling her and saw faces in several different places e.g. in flowers, in food and in a window. She reported she had been in four motor vehicle accidents from December to January 1994 due to blackouts when driving. It was suggested that she suffered from dissociative reactions but no diagnosis was made.
During my first interview, she complained she had been depressed and agitated for four years. She was less depressed while on Prozac but was still having problems with her eating disorder. A mental state examination revealed a large variety of perceptual symptoms including hearing voices, seeing visions. There were voices of several men. There was also a change in taste perception. She could not tell the difference from the hallucinations and real phenomena. She was also very paranoid and suspicious of her family and friends. I disregarded all the previous diagnoses which totally ignored her main symptoms and diagnosed her schizophrenia. The mean score for schizophrenia is around 65. Few patients with other diagnoses score over 30 and all normal people score less than 20. On the HOD test she scored extremely high, as follows Total 152, Perceptual 36, paranoid 9, depression 16 and short form 14. The odds she was schizophrenic were over 90%. I started her on niacin 500 mg tid, ascorbic acid 1 G tid, pyridoxine 250 mg od and zinc citrate 50 mg od. Orthomolecular therapy includes the combined use of diet, nutrients in optimum amounts and drugs as needed.
Three months later she was free of voices. A month later I heard from the referring physician to express his pleasure at seeing how well she now was. He added "She is almost unrecognizably improved". June 11, 1996 she and I estimated she was 80% better. She stated that she felt normal for the first time in five years. In July she continued her improvement. She had visited her mother with her three children and had enjoyed the visit. When she had been depressed and paranoid her psychiatrist had stated that she had a poor relationship with her parents. This was apparently not the case. Her HOD scores were now normal. She was still on niacin 4.5 G od, Prozac 20 mg od and the rest of the vitamin regimen.
From the time I had first seen her there was one more visit to the Emergency Department of the Hospital. In 1992 she was seen in the Emergency 6 times. In 1993 she was seen 12 times with one after an overdose of drugs. In 1994 she was seen 16 times after 9 overdose attempts and spent 95 days in hospital. In 1995 she was seen 16 times with 2 overdoses. (Fifty visits to Emergency Services over a four year period with 12 suicide attempts and a total of 101 days admitted to hospital.) She started orthomolecular treatment on December 18, 1995. So far (November 1, 1996) she has been seen once in the emergency services.
Scientifically, when a phenomenon (this patientís history of illness and repeated admissions) suddenly changes direction after a new variable has been added, one must assume that the change in direction arose from the application of the new variable. Consider the course of her illness as an object moving in a straight line. Several pressures are applied but the object remains on course. However when the course is abruptly altered after the application of a new force then one can conclude there has been a true effect of the new force on the course of the illness i.e. that orthomolecular treatment caused her marked improvement.
Hoffer A, Kelm H & Osmond H: The Hoffer-Osmond Diagnostic Test. RE Krieger Pub Co. Huntington, New York, 1975.
Hoffer A: Orthomolecular Medicine for Physicians. Keats Pub., New Canaan, CT, 1989.
Hoffer A & Osmond H: How To Live With Schizophrenia. University Books, New York, NY, 1966. Also published by Johnson, London, 1966. Written by Fannie Kahan. New and Revised Ed. Citadel Press, New York, NY, 1992.
Hoffer A: Chronic schizophrenic patients treated ten years or more. J. Orthomolecular Medicine, 9:7-37,1994.
Hoffer-Osmond Diagnostic Test (HOD)
for Orthomolecular Therapy
Hoffer A, Kelm H & Osmond H: The Hoffer-Osmond Diagnostic Test. RE Krieger Pub. Co., Huntington, NY, 1975.
The HOD Test Kit is available (in English only) from Behavior Science Press, Institute For Social and Educational Research, 3710 Resource Drive, Tuscaloosa AL 35401-7059, USA.
A Chronic Schizophrenic Woman Comes
Back to Life
Lena came to see me in October 1988 with her father. When they walked into my office my first impression was that she was either severely retarded or a chronic deteriorated schizophrenic. I obtained the first history from her father, as she was not able to tell me anything. She sat looking to one side the whole time. Her father complained that she suffered unusual blotchy skin, and her hands became very sweaty when she became excited. Her parents were surprised when in grade 6 they were told that she was not able to learn. From then on she went to special classes. About one month before she came to see me she had fallen asleep in her chair and had spent the night there. Her parents awakened her. She accused them of trying to drown her and ran away. The police picked her up, called her parents and she went home with them. The mental state examination revealed only that she was paranoid believing people were saying nasty things about her. I concluded that she was an adult learning-disordered person which had been present from childhood.
I started her on niacinamide 1 gram after
each meal, the same amount of vitamin C, pyridoxine 250 mg each day and
zinc gluconate 50 mg each day. Six months later her skin was normal, she
was less depressed, had more confidence in herself and found it easier
to communicate. She was no longer paranoid. But during July 1988 she had
to be admitted to hospital. This time she complained about hearing the
voices of her father or mother when they were not present. I rediagnosed
her chronic schizophrenic.
January 1993 she was on 25 mg of the drug plus the same vitamins. She was less sleepy, cheerful and much more communicative. I kept on reducing the drug but in the end of 1994 had to increase it back to 50 mg. Early in 1996 the drug was down to 25 mg. She came to see me July 1996 very excited. She was free of all symptoms. She brought along her math test results and had made 100 percent. She proudly showed me the certificate she had received for her scholastic performance. She was a better reader than the other patients in her class and was not afraid to read in front on them. She told me that she was very happy because for the first time in many years her parents who had not been getting along had reconciled and they were enjoying each other's company again.
The woman I had seen 8 years earlier no longer existed. She had been transformed from a sick looking woman who had the appearance of a retarded person as used to be portrayed in old text books of psychiatry to a young woman who dressed well, and spoke freely to me. When I first saw her, and for several years, she would always talk in response to my questions but would look off to the side. She enjoyed coming to the office, and especially enjoyed saying hello to my secretary and getting a hug from her. I wrote to the referring physician "It is always a delight to see how much improvement Lena is showing as I continue to see her. Today she was feeling really good, was very cheerful and she was especially delighted because her parents, who apparently had not been talking to each other for years are getting along very much better. I think she is doing great."
My criteria for recovery are very simple (1) There must be no symptoms and signs, (2) The patient must be getting on well with family (3) The patient must be getting on well with community and (4) The patient must be employed i.e. paying income tax. Lena has achieved all four but does not earn enough to pay tax. She has been sick so long that the handicap of those lost years has not yet been resolved. But she is learning more skills in a fine program designed to rehabilitate patients. Without the vitamins she would have remained the same dowdy, retarded appearing women with no hope of ever getting any better.
Lena is one out of several thousand I have seen. Why are chronic patients elsewhere denied the opportunity to get well?
One of the advantages of the orthomolecular regimen is that patients are more compliant since they do not suffer major side effects and when they have to take drugs the dose is so small that for this reason side effects are minimized or avoided.
Side effects may have been a main factor in Manley Eng's criminal career and will force him to remain in prison for 11 years. Mr. Eng was found guilty of arson and was found to be schizophrenic. He refused to take medication because it left him feeling lethargic and stupefied, (Wested, 1996.) I have seen numerous patients who could not remain on the medication because of severe side effects.
This anecdote illustrates the following
Wested, K. "Unrepentant arsonist gets stiffer sentence." Times Colonist, Victoria June 25, 1996.
Twenty Years On Orthomolecular Therapy
April of 1977 he had suffered an infected finger requiring 7 days in hospital and two operations. He had also broken a bone in his heal. He had not been taking his Haldol and he began to hear himself think. (This is a classic schizophrenic symptom). One month later, back on Haldol 2 mg, he was well. By the end of the year the Haldol was decreased to 1 mg daily. In March 1978 I increased his niacin to 1000 mg three times daily. July he was normal but still needed tiny amounts of Haldol. I increased his niacin to 1500 mg three times daily. By February 1983 he was normal and no longer needed any medication. In January 1983 he became depressed again and had to resume his Haldol which he maintained for a couple of years. I also added 25 mg of amitrytiline and 2 mg of perphenazine to his program. May 1989 he was normal. He was a very busy contractor building houses and had moved to an acreage. October 1960 he came to see me. He was worried that he was not facing stress adequately. But he had observed that whenever he ate sugar he became worse. He still needed to take small amounts of the combination of the anti depressant and the tranquilizer. He was normal, very busy as a contractor and looking after his family and his aged parents. He had built a house for them on his property so that he and his wife could look after them properly. He meets my criteria for recovery in spite of the fact that now and then he needs some help with medication. In this he does not differ from patients with other chronic diseases. Patients on megavitamin therapy usually require much lower doses of tranquilizers and thus can avoid most of the side effects associated with the usual dosages that are in use today.
Had he not been placed on vitamins by the first psychiatrist who treated him and which I continued and modified there is little doubt he would be receiving welfare, on a variety of major drugs and not a major contributor to Canadian and BC government coffers. A small investment in vitamins converted him from a chronic schizophrenic consumer of everything to a major contributor to society.
Patients Not Schizophrenic Also Respond
to Orthomolecular Therapy
Lorraine, born in 1961, suffered from restless leg syndrome present for two years. Neurological examination showed no reason for this. She suffered from weak legs, unsteadiness and if she walked a lot extreme fatigue. Mainly she suffered from an uncontrolled urge to move her legs when awake. This made it very difficult for her to fall asleep and she suffered from sleep deprivation. She was given several diagnoses including chronic fatigue syndrome. On her own she began to take small amounts of a few vitamins and believed this had been helpful. I advised her to take niacinamide 500 mg after meals, vitamin C 1000 mg after meals, folic acid 15 mg daily, vitamin B-12 l mg sublingually daily, lysine 1000 mg after each meal, vitamin E 400 iu daily and zinc citrate 50 mg daily. November 18, 1996 she was normal. An anti depressant, Paxil, she had been taking two years had not helped and she had to discontinue it because of side effects.
Lee, born in 1963, was very anxious and tense. For years he had controlled this by using alcohol. He would binge every three to four months for one day. He suffered blackouts and often committed irrational acts that he did not remember later. I started him in niacin 500 mg after each, meal twice as much ascorbic acid and folic acid 5 mg twice each day. I have been using niacin for alcoholics for the past 30 years. This treatment was first widely publicized by my good and close friend Bill W. Co founder of Alcoholics Anonymous. He circulated a treatise called The Vitamin B-3 Therapy to physician members of AA. I had advised Bill to take niacin 3 grams daily to control his severe tension, fatigue and insomnia. Within two weeks he was well. When I saw Lee for the second time in mid November he was almost normal and no longer needed to be seen.
Frank, born in 1962, had three complaints when he saw me September 30, 1996. He was very anxious and fearful, was unable to stick to any particular line of activity and could not cope with stress. During his teens he had experimented with LSD, with pot, mushrooms, cocaine and alcohol. At age 17 he began to consult various therapists and take many self help courses, spending about $30,000. I found that depression and anxiety were the main features. I started him on niacin 500 mg after each meal, on twice as much ascorbic acid, and on folic acid 5 mg once daily. By mid November he was nearly well. He was able to concentrate better, was better focussed, his mind was clearer and his mood was better and level. I then doubled his niacin amd folic acid for maintenance. He no longer needed to be seen.
Marion, age 32, consulted me October 2
because she suffered from chronic fatigue and was unable to cope with recurrent
infections. She had been diagnosed bipolar psychosis (manic depressive)
and had been on and off lithium for 13 years. When on lithium her mood
cycled very rapidly. In mid July she was diagnosed depression and started
on an antidepressant which was very helpful. But when I saw her she told
me about the voices she had heard in the past, about her paranoia, poor
memory and difficulty with concentration. I started her on a dairy free
diet with ascorbic acid 1 gram after each meal, pyridoxine 250 mg daily,
zinc citrate 50 mg daily, selenium 200 mcg daily and a B complex 50's once
daily. By November 18 she was well. She had started to improve about ten
days after starting on the program. She was not able to tolerate the selenium.
Seeing four non schizophrenic patients in one afternoon who had gotten well or nearly well after two visits reminded me that orthomolecular therapy should be made available to all psychiatric patients.
March 4,1997.Last week I discovered that I had saved British Columbia and Saskatchewan piles of money by practicing orthomolecular medicine. I concluded this after hearing from four patients I had treated in the past.
1) During July, 1996, I saw a young woman, born in 1968 who had suffered a post partum depression for which she was treated in hospital on two occasions. She was treated with risperidal, one of the three most modern tranquilizers. She heard voices when she was pregnant, still heard her own thoughts and was delusional believing that her four year old son was an Antichrist. She was also preoccupied with the death of her brother who had been killed in a car accident. He had been my patient in 1972 and had recovered from his schizophrenia. She was also very depressed and fatigued. I advised her to eliminate sugar from her diet, to take niacin 1 Gram after each meal, vitamin C 1 Gram after each meal, folic acid 5 mg after each meal, pyridoxine 250 mg daily, zinc citrate 50 mg daily and a B complex 50's once daily. She remained on the risperdal 6 mg daily. In March I doubled her niacin dose and in July increased it again to 3 Grams after each meal. The following November her local psychiatrist decreased the drug to 4 mg. February 26,1997 she called. She was well but was worried about her son who was typically hyperactive with a short attention span. I advised her to put him on a sugar and dairy products free diet and to add a simple B complex preparation for children. She had observed that a Coke would drive him wild.
Had she remained on the drug only the odds are over 90% she would have remained permanently ill and would cost British Columbia $2 million over the next forty years.
2) The same morning I received a call from Saskatchewan from a woman born in 1924. I had seen her in Saskatoon many years ago. She had been suffering from severe Meniere's disease which had not responded to any medication nor diet. On her own she had started taking small amounts of niacin and for the first time began to get better. She came to Victoria in December 1987 with her husband and consulted me about her orthomolecular program. Both were normal. I suggested she remain on the niacin 1 gram three times daily, the same amount of vitamin C, some vitamin E and B complex 50's. In 1993 she reported that she was normal but she was worried about her husbands arthritis. He was two years older. He too was started on a vitamin program. February this year she called again and told me how pleased and delighted she was at their good state of health. Both were symptom free, They were both leading a wonderful life, she said. That last call saved Saskatchewan the cost of two consultations but even more saved the cost of recurrent consultations at home with their family doctors and specialists if they had not started on the megavitamin regimen.
3) An elderly man called from Victoria where he had been visiting his family. He had wanted to see me but his wife died suddenly and he could not. He reminded me that I had treated his daughter between 1970 and 1972 for schizophrenia with the vitamin program. She had recovered, got better each year. Her two children were attending University. He was delighted with her recovery. Her recovery saved Saskatchewan $2 million. She has been well and productive for 25 years and there is every indication she will not relapse. On tranquilizers alone she would still be ill, a burden to herself, to her family and to her society.
4) A former patient I had treated in Saskatoon 25 years ago wrote about his mother-in-law and her identical twin sister, He gave me a progress report on his own recovery every year end. The twins were born in 1910. They married brothers when they were 25. His mother-in-law was financially better of and her lifetime diet was more nutritious. In 1966, following a series of difficulties and frequent moves the sister began to show signs of psychiatric illness. She fabricated stories for example. Four years later she left her husband and worked. By this time her diet had deteriorated even more and she basically lived on tea and toast. Eventually she had to be admitted to a nursing home and was diagnosed Alzheimer's disease. She died in 1981.
As soon as this sister was diagnosed my
informant became worried about his mother-in-law because of the hereditary
factor and started her on a good multivitamin multimineral program, including
the B vitamins and vitamin C and E. She remained well on this program.
Today her son-in-law describes her as an alert eighty-six-year-old person.
Today, March 11, 1997, a ninety-four-year old woman came to see me. I had been seeing her since 1992 because of her anxiety over breast cancer. This time she had been experiencing a lot of difficulty from congestive heart failure which was improving. She had been driven to my office by a patient of mine who had been a chronic paranoid schizophrenic. And this is the point of this anecdote. She told me how kind he was to her, that he took her for walks, drove her around and was very supportive and helpful. He represents a patient who had been very sick, had been fired from his job as a nurse twelve times, and even after his recovery could not get a job because the hospitals judged him only on the way he had been, and refused to accept my opinion that he had recovered and was able to work. He is a normal man who has been on permanent pension, even when he did not have to be, because of the popular view that no schizophrenic can ever recover. Of course this is true if tranquilizers alone are used. I saw him first in 1983 when he brought with him a list of 52 problems. By then he had been ill for several years and had been in hospital two years before for three months. He told me about his visual hallucinations. Once he awakened at night and found two men in his room who were trying to awaken him, and they were both ice cold. He heard his own thoughts and felt unreal. He was extremely paranoid, felt people wanted him to kill himself, there was a lot of blocking and his memory and concentration were very poor. No wonder he was so depressed. I assumed he was potentially violent although he had not been violent but he had written threatening letters. I started him on treatment. By 1984 he had recovered. He wanted to go back to work at the hospital but the hospital would not take him after another psychiatrist had maintained that he was still not fit to work. His behaviour had been so paranoid they refused even to consider him. Since then he has been well. He is kind, considerate, helpful to his neighbors. He travels each year with individual members of his family with whom he has a good relationship. He does a lot of volunteer work. Still it is sad that the services of this good man have been rejected simply because he had been so sick in the past. My 93 years old patient is very grateful and appreciates his help. I doubt she knows anything about his previous history. He meets my criteria for recovery i.e. he is free of symptoms and gets on well with his family and with the community and he would be paying income tax if his past had not been used to prevent him from ever working again.
The 26th Annual International Conference. Nutritional Medicine Today (April 18,19,20. Royal York Hotel, Toronto) was a very successful conference with over 150 participants including 100 physicians. We discussed the treatment of depression and schizophrenia the first half-day session. Dr. Sherry Rogers gave us a remarkable outline of the causes and the treatment of depression. She is a specialist in environmental medicine in private practice in Syracuse, N.Y. Her books are excellent and she is a very skillful informative lecturer.
Then Dr. J. Smythies outlined the modern
view of the relation of the aminochromes to normal and schizophrenic brains.
The original transmethylation hypothesis developed by Dr. H. Osmond and
Dr. J. Smythies in 1952 led to the adrenochrome hypothesis of Hoffer, Osmond
and Smythies. Dr. Smythies was Chairman. Department of Neurosciences, University
of Alabama, for many years. He is retired but is a Senior Research Fellow
at the Institute of Neurology in London and is in the Brain and Perception
Laboratory, Department of Psychology, U.C.S.D., La Jolla, CA, and very
active in continuing his writing for medical and psychiatric journals.
I was delighted to see John again after about a ten years hiatus. In his
lecture he outlined the massive evidence that these aminochromes (adrenochrome
is one a number of similar compounds) are intimately involved in the functioning
of the brain. Some of this is discussed in his report "On the Function
of Meuromelanin" Proceedings of the Royal Society (London) B, 363,
491-496,1966. Also in the Journal of the Royal Society of Medicine,
"The Role of ascorbate in brain: therapeutic implications". May 1996, Volume
89, Page 241.
Dr. David Horrobin Is President of the Schizophrenia Association of Great Britain, Founder and Research Director of Efamol Professor at Wolverhampton University and the University of Dundee and one of the foremost experts on the essential fatty acids. In his discussion he referred to a new finding which will markedly simplify the recognition that schizophrenia is present. This ought to introduce some diagnostic clarity and prevent many of these unfortunate patients from being labeled incorrectly as bipolar or borderline personality disorders. He has developed a simple skin test. An adhesive strip containing four different concentrations of niacin is placed on the skin and left there five minutes. The strip is removed. Normally the niacin in the patch will cause some reddening; a mild flush or dilatation at the point of contact. Non schizophrenic people are much more sensitive to this effect while schizophrenic patients are not. About 70% of the schizophrenic patients will not flush at levels which will flush normal people. This test may soon be available commercially. His report created great interest at a previous meeting in the USA where he presented this finding.
For more information:
Schizophrenia and Crime in Victoria
Rick Cooper of the B.C. Schizophrenia Society said there are few supports for these sick people, that there is no one responsible for ensuring that they take their medication regularly, that there is almost no treatment provided for patients not in hospital. The chief of police reported that crime by mental patients had increased from about 200 each year to around 250 in 1996.
The Times Colonist, July 5, 1997 carried more information. The paper quoted the father " During the past few weeks I have heard dozens and dozens of real-life stories from strangers and friends alike about other families of schizophrenics who were at their wit's end, abandoned by a health system that had little to offer unless a crime had been committed".
In their communications with the public the mental health associations and the professional people involved in the care and treatment of schizophrenics have maintained that these patients are as law abiding as the general population. There are two aspects to the crime problem; these are the quantity and the quality of the crime. It is true that schizophrenic patients are not more prone to commit crime than are the average population but it is also true that schizophrenics are much more apt to commit strange, bizarre and totally illogical crimes than are the rest of the population. That is because they commit their crimes in response to their hallucinations and their thought disorder. Thus, many years ago a man was committed to hospital in Regina because he was chasing a young girl on the main street. When I examined him he told me he had seen a vast illumination in the heavens as we was walking west in the late afternoon and that from this illumination he heard a voice say "You have syphilis and to be cured you must have intercourse with a virgin". He had both a visual and an auditory hallucination and he thought the voice was the voice of God and must be obeyed. He recovered on megavitamin therapy and remained well thereafter.
Another case was the Hoffman, case in northern Saskatchewan, Kahan (1975). A schizophrenic young man was in the Saskatchewan Hospital, North Battleford on medication. In hospital he described his hallucinations to his psychiatrist. He heard and saw both the Devil and his guardian angel. They were fighting with each other. The angel wanted him to be good and the Devil tempted him with the world's riches if only he would kneel before him. His psychiatrist ignored these symptoms. He was discharged and given a months supply of medication. A few weeks after he ran out of the drug the Devil came to him at night, following a splitting headache. He described him as a 6-foot 2-inch huge man with the face of a pig who ordered him to get into his car, to drive exactly 60 minutes and wherever he then was to kill. He stopped at the Hoffman farmhouse, and shot and killed every member of the family except a baby who was crawling on the floor. By then, he told me, he was too tired of killing. He was found not guilty by reason of insanity and was committed to a mental hospital.
The criticism hurled at the community mental care supports and facilities are always directed against those matters which appear to be most important such as not enough beds, not taking ones medication, not enough community supports. They can all be described as factors which can be healed by throwing more money into the system. With more money there would be more psychiatrists, more beds, more community support nurses, more follow-up workers, better shelters and so on. While these are all needed one of the most important aspects of the problem is totally ignored. That is the need for more effective treatment. The situation can be blamed squarely on the psychiatrists who insist that the only treatment of value is the use of drugs. But these drugs, while controlling symptoms, do not lead to recovery. On the contrary, it is impossible to be well while on tranquilizer medicine. The side effects are so troublesome that too many patients refuse to stay on the medication unless they are forced to in hospital or by injection. If we are going to have any impact on the intensity and quality of the crimes we must improve the quality of treatment. Psychiatrists must be made more accountable for the results they are getting. Psychiatric Institutions must be made forced to release annual reports showing what proportion of their schizophrenic patients have recovered and why they are not doing any better. They must be forced to examine seriously at orthomolecular psychiatry which yields results very much better.
Around 1968 a young man took his rifle, went to his parentís bedroom and fired the gun at the pillow between their heads. No one was hurt. He ran from the room and out into the mid winter snow and cold (forty below) in his bare feet. I found him to be schizophrenic. I described the situation to the judge who released him to my care at City Hospital in Saskatoon. I treated him with megavitamin therapy. He recovered and when I last heard from him, he was happily married living somewhere in Northern Canada. A second example was a graduate student in physics at the University. He was shooting at cars driving down the road. He was referred to me. I found him schizophrenic. He had a history of illogical, silly and dangerous acts. For example on one occasion he hid in the stacks of the public library in Washington D.C. and when everyone had gone home he enjoyed himself by pushing all the stacks over. I started him on vitamin therapy. Three months later he was in a cold sweat with anxiety. He told he had just realized that he might have killed someone. He continued treatment, was released by the court on condition he return to the US. Last I heard he was a professor in physics in one of the mid-west Universities in the US.
I do not claim that every patient will be treated as successfully as this. But I do claim that many more will and that we have to improve the quality and quantity of treatment for all patients so that the proportion of the crimes committed by them will vanish. Every person charged with a crime which contains the elements of the bizarre, the difficult to understand, the illogical acts, should be examined to find out what the determinants of that behaviour were so that appropriate treatment can be started and combined with punishment in most cases. Punishment alone is of little value. Treatment without punishment is better but best of all would be good treatment program combined with minimum punishment.
Kahan, F.H. Schizophrenia, Mass Murder and the Law. J. Orthomolecular Psychiatry, 2,1256-146, 1975.
Today (July 5, 1998) Sixty Minutes described the tragic story of a New York family who adopted a son from a respected, not-for-profit adoption agency. He was intelligent, fit, interested in sports and loved by his family as he in turn loved them. In his mid teens he began to skip classes, later became clearly paranoid and eventually was admitted many times to New York hospitals for treatment of his schizophrenia. After several years the family and especially the adopted son tried to obtain information about his parents, especially his mother but the institute would, at first, not release anything and later under pressure informed the son that his mother had episodes of depression. It was common policy for adoption agencies everywhere not to release information about the parents of the children they placed. In many areas this is now mandatory. The family sued the institute and after seven years it has still not been settled. But the court ordered the institute to release their file. The file reported that his mother had been a chronic schizophrenic patient, that she had been lobotomized, and had spent time in hospitals. They also found that the father had been classed as mentally ill. In the mean time their son continued to suffer, continued to have treatment and eventually died at age 29, from a drug reaction. The name of the drug was not given. I would guess it was clozapine because it is used for refractory patients and it does kill a very few patients.
The Sixty Minutes report concentrated on the tragedy and the loss of the son to his family as a result of the failure of the institute to provide the essential information. However one must ask What difference would it have made? Suppose the institute had given them the information that his mother was schizophrenic, that 10% of children of one schizophrenic parent will become schizophrenic, that if both parents are ill half the children will become ill. The parents might have decided that since there was a 90% chance the child would not become schizophrenic that they could live with these odds. But in either case, knowing the odds, or not knowing anything about the mother the outcome would have been exactly the same for with orthodox, xenobiotic treatment there is no way by which they could have prevented the illness or treat it properly. This is the real tragedy of this very sad anecdote. But it could have been different. The parents should have been advised of the motherís illness. They should have provided information that if there was any significant change in behaviour or learning ability of their child they should promptly seek help from an orthomolecular psychiatrist who could start the correct treatment and that this is the only way this tragedy could have been avoided. In New York City, The Fryer Research Center, at 30E 55th St, 10016, 212 808 4940, has been treating schizophrenic and other patients with success for at least the past 25 years. This center might have helped this desperate family seeking help for their son.
The following anecdote illustrates an entirely different outcome. In 1960 Bill W., the co-founder of Alcoholics Anonymous, asked me to see a girl, seven years old. Anabel was adopted by her grandfather and his second wife. Anabel's mother was a chronic schizophrenic patient, in a chronic back ward of one of the mental hospitals. I knew Anabels mother having treated her at University Hospital in Saskatoon for a couple of months. She was well after discharge but could not find anyone in Washington D.C. who would continue the program. She eventually relapsed and went back to hospital. Anabel's adopting parents were very worried because she had been diagnosed retarded, and it was very difficult to deal with her behaviour. She was being prepared to go to a special school in New York City for the retarded. Knowing the odds she might be showing the earliest manifestations of her mothers illness I advised them to start her on niacinamide, 1 gram three times each day after meals. For two years there was no change and then she began to get well. She graduated from university on the Dean's Honor list. Later she married, raised a family. She became a piano teacher. I was in contact with her a few months ago. She is still well. Had Anabel not been treated with this B-3 vitamin I have no doubt she and her family might have suffered the same fate that enveloped the family of the young man who was killed by a drug. By the way each year, in the United States and Canada, over 110,000 patients die from the proper use of drugs in hospitals. I think it would be logical for the family also to sue the hospitals who did not treat their son with the most modern and most effective treatment. Antipsychotic drugs, used alone, do not allow schizophrenic patients to become normal.
Starting a Schizophrenic Patient on
With his mother's assistance I completed a mental examination. He had perceptual changes including visions of the Devil. He did not hear voices but did hear himself think. He was paranoid although it was not as bad now as it had been. He had believed he would be poisoned, that the Devil was after him and he believed people were staring at him. He had been very depressed, and still was very tired, sleeping 16 hours each day. He also gained 50 pounds while on Olanzapine and was beginning to look very pudgy. I advised him to follow a dairy free and low sugar diet. To this he was to add niacinamide 1 gram after each meal, the same amount of vitamin C and one B-Complex 50's tablet each day. This was added to the Olanzapine. During the interview I outlined for him my version of what I think schizophrenia is, why I was advising him to take these nutrients and why I wanted him on this diet. His mother told me that as a child he had been very allergic to milk. In the hospital he drank three glasses of milk each day and continued to do so at home. Also in hospital he learned how to become a heavy smoker. The psychiatric ward had the only smokerís room in the whole hospital.
He will be seen again in about three months.
He can not come more frequently since he lives too far away from Victoria.
His treatment will be monitored by his local psychiatrist and by his family
doctor. Every time I see him I will add a progress note to this report.
This running report will illustrate the process of orthomolecular treatment.
October 7, 1998. His mother called to cancel his appointment. She reported
that he was going to school and did not want to miss classes and that they
would call again for another appointment. This indicates to me that he
is already substantially better since he is now able to concentrate on
his studies and felt this was more important than visiting me many miles
from his home.
I asked her to eliminate sugar from her diet, to add niacin, 500 milligrams after each meal, and eventually to increase it to 1 gram three times daily. To this I added vitamin C 500 milligrams after meals, folic acid 5 mg after meals, pyridoxine 250 mg each day and finally zinc citrate 50 milligrams each day. I reassured her that if she followed this program her chances were very good that she would be much better within 6 to 9 months. Her intense anxiety and panic arose from her intense paranoid ideas. She came again with her father February 15, 2000. Her father told us that he had seen tremendous improvement in two years, much more than she herself felt had occurred. She knew she was getting better steadily but she was still concerned about anxiety which was not as bad as before and she was worried that she found it difficult to interact with more than one person at a time. She also had more insight and became aware that during childhood she had major problems controlling her thinking. She wanted reassurance that she would eventually become normal. I assured her that I thought this would occur over the next year or two during which time she would continue to improve. She spoke about her family and how she felt inferior and strange because she could not think as quickly as they could and that she felt comfortable only with her close friend. This is a phase that patients with schizophrenia often have to go through. They are much better and realize how ill they have been. Support and counseling are very helpful during this phase as is understanding from family and friends.
She came back October 5, 1998. She was significantly better, felt less unreal, was less paranoid, had more insight and was beginning to regain social skills that her disease had removed from her. Her artistic skills were coming back. She had gone off her antidepressant and vitamins for a week and during that week suffered a relapse with severe fatigue and more difficult paranoid ideas. In the past when, on occasion, she smoked pot she would become catatonic. This time when she smoked pot once this did not happen. I estimate that she is about 25% better. She was pleased as was I. I did not change the program.
February 1, 1999 she told me that two weeks
ago she became aware that she was beginning to recover. Her thinking had
become more organized, her mood was level, she had more energy. She had
developed severe side effects to the anti depressant she had had to take
before. She discontinued the medication and continued to improve, She suffered
much less pain and had fewer perceptual abnormalities. She still had a
major problem. She was too jealous but she recognized this was a problem.
This is called being paranoid with insight. She was troubled by this and
I reassured her that this too would gradually disappear. I increased the
niacin to 1.5 grams after each of three meals. She was concerned about
her partner and had arranged that he too would be referred.
February 24, 1999 I saw her partner. His main complaint was that he could not think clearly, that he suffered from irrational ideas, that his short term memory was non existent and that he had zero concentration. As a result he had to be supervised by NS even to minor matters such as reminding him to eat. She had advised him to start on vitamins and he took niacin 1 gram each day for the month before I saw him. In that month he improved significantly, found his brain was coming under his control. I increased his niacin to 1 grams three times daily and asked him to continue the program NS had advised him to follow.
When seen last in November there was no doubt NS was better, was better able to function. I increased her niacin again to 2.5 grams, three times daily (7,500 mg total) and added one gram of salmon oil, for its omega three content, three times daily.
Murder in Washington, D.C.
Psychiatrists report that patients with schizophrenia are as law abiding as the general population. This is true. The same percentage of each group will commit antisocial acts. But there is a major difference. The schizophrenic criminal is most apt to act out bizarre delusions or fantasies and, therefore, when s/he does commit a crime it will be more bizarre and much more difficult to understand. It is, in fact, easily comprehensible if the criminal will tell what the hallucinations and delusions were.
According to an Associated Press report, Democrats and Republicans in Congress asked the National Alliance for the Mentally Ill to draft suggestions on improving mental-health care. I doubt NAMI will ask the right question. NAMI appears to be content with the psychiatric treatment offered by psychiatrists and they devote their attention to other matters such as a having facilities available. In any treatment program the following measures are important (1) the medical treatment -- this includes good nutrition and psychiatric care, (2) the site of the treatment, the shelter i.e. hospital, home, the streets (3) the ancillary care i.e. from nurses, social workers, psychologists and so on. I found many years ago that of these, the most important was the medical treatment. In other words, orthomolecular treatment, even in a very low quality hospital or home is better for the patient than standard tranquilizer treatment in the best possible psychiatric ward. About 30 years ago, I found that the response to my treatment of a large number of schizophrenic treatment-failures from all over North America was the same when they were housed in a nursing home for $20 per day, compared to my results with similar patients treated in a University Hospital, for $80 per day. From over 100 chronic patients who came to Saskatoon to the nursing home, half returned to their homes in USA and the rest of Canada much improved. They were in the nursing home less than three months. They had previously failed to respond to many admissions to the mental hospitals from their own region including the Menninger Institute, then considered one of the best.
October 8, 1998. Three years ago Max arrived in my office from the mainland. He was 18 years old. He complained that he could not concentrate, had very poor recall and was very tired. He became depressed two years earlier and had to drop out of grade 11. After that he began to neglect himself, lost interest in his peers. The anti depressant Paxil did not help, nor did Manerix. At the end of 1994 he was in hospital. After discharge he deteriorated further. He drank excessively, began to hallucinate voices and visions and on one occasion was found confused and disrobing on the street. He was admitted for two months. This time he was placed on resperidone, 6 milligrams daily, the modern tranquilizer and surmontil one of the older anti depressants. His first diagnosis was bipolar later changed to schizo-affective. His mental state was fairly typical with hallucinations which be believed to be real, severe paranoid and grandiose delusions and a lot of anxiety with depression. I started him on niacinamide 3 grams daily, ascorbic acid 3 grams daily, pyridoxine 250 milligrams per day, zinc citrate 50 milligrams daily, selenium 200 micrograms daily and vitamin B-complex 50's one each day. He remained on his medication as well. In August of 1997 he was started on lithium carbonate, 900 milligrams each day.
I saw him in October 1998 for the twelfth time, (in three years). In the meantime he or his family had called me about six times. During this last visit he happily told me he had graduated from Grade 12 with a ninety average and was planning further studies. He was free of perceptual complaints, and his thinking was good although he still found it difficult to concentrate. His mood was level but a bit too flat. He was on niacin 2 grams per day as he could not tolerate any more. His resperidone was down to 1 mg daily and he planned to decrease it to 0.5 mg.
December 1999 he had improved even more. He was taking post grade twelve courses and making a B average. He had been able to deal with a moderate depression starting about two months earlier and ending one month later. His resperidone was down to 0.25 mg daily and Paxil 30 milligrams daily. I added salmon oil, 3 grams after each meal, to help stabilize his mood even more. He was relaxed, alert, communicative, free of symptoms; in fact he was normal.
Assuming he remains as well, or even better, his recovery will save the province of British Columbia 2 million dollars over a forty year life span. But like most psychiatrists the province refuses to take this work seriously. His family are very pleased.
Edmond Yu, born Oct 2, 1961 was killed by police bullets, February 20, 1997.This is another tragedy which could have been avoided had Edmond been treated for his schizophrenia using Orthomolecular Methods. The Toronto Star, October 3, 1998 under its Insight Section Headed the story "Edmond Yu's mental illness killed his dreams. But it was the way we treat the mentally ill that eventually killed him". But the writer, Scott Simmie, was not being critical of the psychiatric treatment offered this young patient. The tenor of the report is that society somehow failed by not paying enough attention, by not providing enough support, by not providing enough of the psychosocial supports that could have been provided. Perhaps had the supports been better he might not have been killed but it is certain he would not have gotten any better because the fault lies, not in the community, but in the psychiatric community which depended solely on the use of drugs, the modern standard treatment for this disease.
Edward was a brilliant student, tops in his classes , who in his second year in medical school became psychotic. He became seculsive, irritable, paranoid and his behaviour became antisocial. His family and friends made strenuous efforts to have him admitted to hospital for treatment but it was difficult because of the illogical mental health laws in Ontario. The authorities decided that he could not be admitted even though he needed help because he was not dangerous to himself or to others. It turned out that he was in fact dangerous, mostly to himself, and to others and that he should have been treated adequately in hospital long enough to stabilize his condition and started on the path to recovery. Eventually he was in the Clarke Institute several times and given the usual tranquilizers. But he would not take them because of the severe side effects including tardive dyskinesia, weight gain and it was impossible for him to study. He could never complete medicine while on tranquilizers. He is described as non compliant, a very common problem when only drugs are used. Eventually he drifted downward and downward ending up in the new mental hospitals of this age, the streets of downtown North America. In Toronto it is the city surrounding the mental hospital on Queen street. He was shot by the police in self defense when they tried to apprehend him.
This is how he should have been treated. When he first became ill and this should have been recognized by the professors of medicine at the college, he should have been seen by a psychiatrist who would have diagnosed him properly and started him on proper treatment using nutrition, medication and supplements. At this stage he would have been much more cooperative and would have stuck to the regimen. As he began to improve he would not have needed so much drug and he would have been spared the side effects which prevented him from staying on the medication. If he had been too ill to cooperate as an out patient he should have been admitted and then placed on the proper orthomolecular program and kept in hospital until he had regained his insight. Then he would have been followed as an outpatient. Had be been given the benefit of this treatment the odds are great that he would have graduated and become a useful physician. I know of 17 young men who became schizophrenic in their teens. They were treated properly, became doctors and went on to have successful practices. Several became professors at medical colleges and one became President of a very large psychiatric organization. But Edward was denied his chance to recover. The fault lies not only in the community but mainly in the psychiatric profession, which stoutly refuses to look at anything but drugs as if they were beholden to the drug companies who make these drugs. The community must be blamed because it did not ask the right question and demand the right answer. The right question is Why do you psychiatrists not do a much better job of treating these patients.
J.B., Born in 1970, came to see me with his parents in August, 1998. He told me that five years earlier he suddenly became catatonic and was admitted to hospital for one month. Since then he was in hospital for twelve admissions, each lasting one to two months, except for the last one when he was admitted to University Hospital for 3 months and then transferred to the closest mental hospital for 7 months. Since then he has been living in a group home on medication.
He had suffered from hearing voices were most often derogatory about him but occasionally he found them helpful. They were not troublesome at the time of my examination. He had thought he was being poisoned in the past and had been very depressed. I started him on niacin 1 gram, three times daily after meals, the same amount of vitamin C, folic acid 5 milligrams after meals, zinc citrate 50 milligrams daily and B Complex 100's, one daily.
He and his parents came into my office two months later. I knew immediately that he was better because all three were smiling broadly. He told me he had more energy, felt better, and a noted a return of a sense of well being. He had started taking courses to complete his high school and in the few examinations made grades over 90%. I increased the niacin to 1.5 grams, after meals, added selenium 300 micrograms twice daily, Evening Primrose Oil 2 capsules daily and increased the B complex to 100's, one daily. Patient and both parents were much more optimistic and we discussed realistically what he would do after he recovered. He considered the idea that he might become a doctor. For readers who think this is a pipe dream, I know personally 17 men who became ill in their teens, recovered and became physicians, some achieving very high professional status. I will add to this report in three months.
He came with his parents on February 24, 1999. He was more relaxed, the voices were less troublesome and he felt better. His psychiatrist in his home town had decreased his clozapine. His mother told me that this was the first time in five years that he had been able to write examinations without decompensating with the stress. His marks ranged in the high A's. He planned to review more of his high school subjects in order to refresh his memory and then to get back to University. He spoke about becoming a psychiatrist. I encouraged him to think this way. We need as many orthomolecular psychiatrists as we can get. All three were pleased with his response. He smiled frequently.
My book "Vitamin B-3 and Schizophrenia" is subtitled "Discovery, Recovery, Controversy" This book contains much of the original data from our double blind controlled experiments conducted in Saskatchewan between 1952 and 1960. The material was too voluminous to be published in medical journals. How To Live With Schizophrenia, has been published in a new edition. "Dr Hoffer's Guide to Natural Nutrition for Children" is through the proof state. It is an answer to the Ritalin craze now sweeping North America. If you value your own health and the health of your family you must read these books.
The 28th Annual International Conference of the International Society of Orthomolecular Medicine (ISOM) on Nutritional Medicine Today was held in Ottawa, Ontario, Canada at the Chateau Laurier Hotel, April 16 to 18, 1999. People who profit from and enjoy these conferences include physicians, other healing professional persons and intelligent lay persons. Seventeen countries are represented in ISOM. "Superman" Actress Margot Kidder was the keynote speaker. She narrates and appears in the film "Masks of Madness: Science of Healing" It is produced by Sisyphus Communications. In this excellent film physicians who treat patients with schizophrenia and patients who were treated successfully appear and tell their story. They pay income tax, one of my hallmark characteristics of recovery. These patients, on drugs alone, would still be languishing in their illness with no hope of recovery. This video is available for sale from the Canadian Schizophrenia Foundation. For more information about the film, contact CSF at email@example.com.
May 6, 1999. Yesterday, while I was shopping with my wife, a man came up to me and greeted me as if he knew me. He told me I had seen him many years earlier and he added he had not had a drink in 16 years. He was well and neatly dressed and buying groceries as my wife and I were. He was still taking three grams of niacin which he thought was great and we discussed the best way to take it. This morning I looked up his file. I first saw him in 1976 in the intensive care unit of the psychiatric hospital. He had suffered from mood swings all of his life. His diagnosis was chronic schizophrenia. He was admitted to a chronic mental hospital in 1970 following abuse of amphetamines. After that he was admitted to many hospitals. He suffered from hallucinations, voices and visions, paranoid ideas, mood swings and was often hyperexcitable. He was very depressed. He had been in several fights, I considered him either suicidal or homicidal. He was admitted again in 1977 to another service and was not given any vitamins. Of course he had also been diagnosed bipolar. He drank a lot and used street drugs. After I saw him again I started him on niacin 1 gram after each meal, and ascorbic acid the same dose. I saw him last August 5, 1981. He had been abstinent for 17 days. His response to niacin and ascorbic acid illustrates once more what can be achieved with chronic patients if they continue to remain on these vitamins for many years.
December 3rd, 1999 Susan Sachs, New York Times, reported in the Globe and Mail, Toronto, the death of Gidone Busch in Brooklyn, New York. A grand jury will begin hearing evidence. The most important question will not be asked. Why was this young man, at age 21 a promising medical student, not treated successfully so that his psychotic actions led to his death. His history as described by Miss Sachs is typically the history of an intelligent schizophrenic person. His father, a retired dentist, described him "He had a mental illness; no question about it" "But he was not a violent person. He was never violent". He was committed to psychiatric hospital three times and there diagnosed paranoid schizophrenia. Will the psychiatrists who treated him be invited to talk about his illness, about the tranquilizers they gave him, about his failure to get well and will they be asked why they did not give him orthomolecular treatment which had a much greater chance of restoring him to normal. I doubt it. Isn't it about time that psychiatry is asked these difficult questions. When surgeons botch up their surgery they are soon called to task by the pathologists. Should we not have the same system for psychiatric failures. Should not psychiatrists use the best treatment, not the most popular ones.
Dr. Miriam Shuchman, Globe and Mail, Toronto, August 24, 1999, in discussing medical mistakes referred to the suggestion by Dr. Don Berwick and Dr. Lucian Leape published in the British Medical Journal that medicine needs to learn from the aviation industry. In the aviation industry the fatality rate has fallen significantly despite increases in volume and complexity. Every major crash is followed by an investigation to consider the causes and how to prevent similar accidents. This I think is a great idea. Every time a schizophrenic patient kills or is killed after treatment there should be a similar intense investigation to consider the causes, and how it might have been prevented by better treatment. About 50 years ago at a clinical meeting for residents and staff I, then one of the professors of psychiatry, made the same suggestion. We were discussing the fact that some patients returned to hospital very soon after discharge. I suggested that we ought to examine every failure to determine why whether it was the difficulty in treating that patient, was it that the wrong treatment had been used, was it anyone of many psychosocial factors. This I explained would allow us to learn much more about treatment and might decrease the number of readmissions. The revolving door policy in psychiatry was just beginning to flower. I was greeted by a sudden chill, a cold silence, not a word of criticism nor support and the discussion continued as if I had not been there.
This is another anecdote describing two female schizophrenic patients, one sick for a short time and the other sick for many years. Mary, born in 1976 , became depressed five years ago and responded well after 2.5 weeks in hospital to antidepressant medication. She remained well until three months before I saw her. This time her depression did not lift even with the same medication. She described it as much more severe. But her clinical diagnosis was schizophrenia since she heard voices which were very real with some insight that they were not real, she suffered shadow illusions, heard herself think, had many nightmares, was unreal and believed that people were staring at her. Often during the day she was disoriented, often paranoid even about her husband, her memory and concentration were very poor and she was very depressed and tired. Her HOD scores were all very high, within the high schizophrenic range. They were total score 105, perceptual score 21, paranoid score 8 and depression score 16. The normal scores are under 30, under 3, under 3 and under 3 respectively. I started her on niacin 1 gram three times each day after meals, the same amount of vitamin C, folic acid 5 milligrams after each meal and zinc citrate 50 milligrams once each day. At that time she was also taking luvox, an antidepressant 150 milligrams , pindolol 2.5 milligrams three times daily, valium 10 milligrams daily and halcion for sleep 0.5 milligrams at bedtime. I saw her two months later and she was normal. She had weaned herself off all the medication. Her scores were 10,2,1 and 1, all normal. She was delighted with her recovery as was her husband. This will be her lifetime program. The other patient, Alice, was born in 1944. She suffered her first depression when she was seventeen and was committed to a mental hospital for three months. She was again in hospital when she as nineteen. I saw her for the first time in 1984 By that time she had been in various hospitals at least eleven times, each admission ranging from 1.5 to 4 months. She had spent 11% of her life in hospitals. Since I first took her on she has been in hospital twice, in 1987 and in 1991 for 2 months each. She remained on the orthomolecular program faithfully and is well. She is now making strenuous efforts to complete grade 12 and later will take a secretarial course. She free of schizophrenic symptoms, gets on well with her family and the community and would be paying income tax if she had not been struck so severely by this chronic illness and if she had been treated properly when she first became ill when she was 17 years old. She does community volunteer work while pursuing her studies. She has been under my care for 15 years. Mary will not repeat Aliceís history because she is being treated with orthomolecular methods.
December 17th, 1999: A young woman brought her psychotic mother. Her mother was guided by her daughter and walked with her eyes closed. I though she was blind and retarded. She was neither. She first became sick in 1960 following a stillbirth and a hysterectomy. Since then she was been in a mental hospital more than half of the time, continually since 1990. Her current diagnosis was bipolar psychosis but not having access to her first admission records I do not know what she was then diagnosed. She was on a two week leave from the hospital so that her daughter could bring her to see me. She had several series of electroconvulsive treatments in the past and was on five different modern drugs currently. But in spite of at least 5 million dollars worth of treatment in the hospital she was just as sick as she had ever been. The new drugs cost at least twenty times as much. Eventually she opened her eyes and spoke briefly to me admitting that she was always hearing voices who told her she was a very bad person and that she had killed people, referring to the still birth. Her daughter had read Miss Margot Kidders account of her recovery, was inspired and became determined to help her mother. Had she been started on niacin in 1960 she surely would have been well in a few years and her life and that of her family entirely different. She was schizophrenic. I do not accept that bipolar patients hear voices all the time and see visions. This is characteristic of schizophrenia with mood swings. But she could have been labeled schizo-affective and the treatment would have been the same. She represents the best that modern psychiatry can do, and it is not good enough. Unfortunately because she has been sick so long and exposed to the sick atmosphere and attitudes of the chronic mental hospital it will take a long time, perhaps up to ten years or longer. But her daughter was determined she would help no matter how long it took. The psychiatric care given to her by the Province of British Columbia so far cost about three million dollars. She is worse today than she was so many years ago because her life has been destroyed by the kind of care given her, by the disease itself unchecked and by the medication she is now on. The retail price of the five modern drugs she is on cost about 450 dollars each month. This should be contrasted with the story of my patient Mary, not her real name, described in How To Live With Schizophrenia. In 1953 after 14 years in a chronic mental hospital she was started on niacin 3 grams each day and we took her into our home for about 2 years. She recovered and has worked since. She retired several years ago on full pension. She was one of the best workers on the cleaning staff of the Royal University Hospital in Saskatoon, Saskatchewan. The cost of treating her after we took her into our home has been well under 1000 dollars for the niacin and vitamin C. These two cases represent the real cost of sloth and inertia in the psychiatric profession. When they recover they pay income tax. When they are treated with or without drugs only they do not.
Tranquilizers cause brain damage. The amount
of the damage depends on the total dose in grams. Thus if a patient takes
100 milligrams each day of one of the older drugs for 1000 days, the total
dose is 100,000 milligrams or 10 grams. One multiplies the daily average
dose by the number of days on that drug. On the internet, L. Stevens, a
lawyer, described the tranquilizer psychosis as follows. " These major
tranquilizers cause misery - not tranquility. They physically, neurologically
blot out most of a personís ability to think and act, even at commonly
given doses. By disabling people, they can stop almost any thinking or
behaviour the therapist wants to stop. But this is simply disabling people,
not therapy. The drug temporarily disables or permanently destroys good
aspects of a personís personality as much as the bad. Whether and to what
extent the disability imposed by the drug can be removed by discontinuing
the drug depends on how long the drug is given and at how great a dose.
The so-called major tranquilizers antipsychotic/neuroleptic drugs damage
the brain more clearly, severely and permanently than any others used in
psychiatry. Stevens referred to Professors Joyce G Small and Iver F Small,
Indiana University, who criticized psychiatrists for using psychoactive
drugs known to have neurotoxic effects. He also referred to Professor Conrad
M Swartz, Chicago Medical School, who reported that neuroleptics relieve
psychotic anxiety but blunted fine details of personality, including initiative,
emotional reactivity, enthusiasm, sexiness, alertness and insight. In addition
to side effects which may be permanent. Professor Jon Franklin in Brave
New Science of Molecular Psychology observed - This era coincided with
an increasing awareness that the neuroleptics not only did not cure schizophrenia
- they actually caused damage to the brain: In severe cases, brain damage
from neuroleptic drugs is evidenced by abnormal body movements called tardive
dyskinesia. However this is only the tip of the iceberg of neuroleptic
caused brain damage. Higher mental functions are more vulnerable and are
impaired before the elementary functions of the brain such as motor control.
Without doubt Stevens has captured the essence of the tranquilizer psychosis.
In a recent report Madsen and colleagues found a significant association
between the amount of tranquilizers taken over years in grams and cerebral
cortex atrophy, (The Lancet, 352, page 784,1998).
March 7th, 2000: I received the following letter. It speaks for itself. " My name is ....You probably receive a lot of letters like this. I wanted to write and thank you for all your research and work in the area of schizophrenia and niacin. Your work really changed my life. A year and a half ago when I was 26, I began hearing voices and experiencing paranoia and panic attacks. I quit my job because of this and quit school where I was working on a second degree in chemistry; because I was losing control. I ended up in the hospital where I started treatment with risperdal. I tried to commit suicide and ended up in the hospital again. The only way I could pay my bills was by the generosity of people from church. For a year I tried risperdal, zyprexa and others. The results were minimal in controlling the symptoms. I also became like a zombie. I could barely work and had trouble walking or doing physical exercise . I gained 50 pounds. I couldnít support myself and relied on the Center for Human Services to provide the $80-a-pill medication. While starting on a new medicine seroquel, I happened to find a reference to niacin for mental illness in a diet book. I looked up the reference and your book How To Live With Schizophrenia. I decided to try the treatment although honestly I didn't believe it would work because nothing else had. After taking niacin in the doses you recommended for a month, against the advice of my doctor, I found while the seroquel was reduced the niacin totally eliminated the symptoms. I could listen to noise again without it overwhelming me and quit having panic attacks. I could think clearly and read normally. The voices are virtually gone. I went off the medication and am doing great, as long as I take the niacin. I did this against the advice of my doctor with his warning. Thank you for all you have done!! I have my life back! I am finishing my degree and thinking of going into further education. I don't understand why this information and treatment isn't made available to others with mental illness and it makes me very angry. Destroyed lives are being wasted. I sent for the medical research you did for my doctor and for myself. If there is anything I can do I would love to. Thank you."
Orthomolecular treatment for the schizophrenias includes optimum doses of vitamin C. These range anywhere from 500 milligrams three times daily to many grams taken after each meal. Patients on this program may be fearful of continuing with their vitamin C following a news report linking vitamin C with clogged arteries. I have already had many calls from my patients after this first report was redigested and puked out on the airwaves with dire warnings of the dangers involved. The Vitamin C Foundation contacted the investigators who read this report at a meeting and discovered that they had measured only one variable instead of the usual three required to shows interference in arterial blood flow. They measured the thickness of the carotid artery wall, but did not measure plaque formation nor for the actual rate of flow through the vessels. The last measurement is the most important one. However they suggested that there was in fact hardening of the arteries and that people with heart problems should avoid taking this vitamin. So here we have another nascent factoid. The facts are that vitamin C decreases plaque formation according to many clinical studies, that clinicians such as Dr Robert Cathcart have not seen any evidence for this in over 30,000 patients. They also ignored the knowledge that thickened arterial walls in the absence of plaque formation indicate that the walls are becoming stronger and therefore less apt to rupture. The original report by Dr James Dwyer, USC was submitted for publication and was not yet reviewed by his peers. Perhaps these peers will persuade the authors to change their conclusion, to simply report what they found and not make these unwarranted recommendations to the public at large. I have not seen any evidence for the Dwyer conclusion in the past 45 years that I have given large doses of vitamin C to perhaps 10,000 patients and at age 82, have been on large doses since 1960. My cardiovascular system seems to be working pretty well. Scientists should avoid the hubris of extrapolations of simple and inadequate laboratory data to the clinical world at large.
The Nutritional Medicine Today, 29th Annual International Conference, Vancouver April 6-9, 2000 was great. Audio Tapes are available from the Canadian Schizophrenia Foundation, 16 Florence Ave, Toronto, ON, Canada,M2N 1E9 416 733 2117, Fax (416) 733 2352 E Mail firstname.lastname@example.org See also www.isom.ca
Orthomolecular treatment of cancer was discussed by John Hoffer and Hugh Riordan. Vitamin C played a major role in these discussions. David Horrobin reported the results of a double blind controlled study, using 2 grams daily of eicosapentaenoic acid, which showed that it was more effective than tranquilizers and much less toxic. This important essential fatty acid should be incorporated into the treatment of every patient with schizophrenia. Dr. Horrobin developed the niacin skin test for diagnosing schizophrenia. Klaus-Georg Wenzel reported that the orthomolecular method, following Carl Pfeifferís classification of the schizophrenias worked well in Germany. He hopes he can complete a double blind study that was interrupted by government interference. David Kennedy reviewed the toxic impact of fluoride especially in children were it caused learning disorders while in sharp contrast to this real and dangerous use of fluoride, Patrick Bouic showed that certain plant sterols improved the function of the immune system. Richard Kunin spoke about ischemia induced apoptosis (cell death) and Tory Hagen showed that dietary supplements could reverse the mitochondrial decay of aging. Mikhael Adams combines nutritional and homeopathic therapy with standard cancer treatment and Isaac Lesser reviewed his new classification of mental patient types and the brain chemistry diet. We were all pleased to hear Stephen Lawson of the Linus Pauling Institute, located in Oregon at the University, bring us up to date on this important institution. It is following in the grand footsteps originated by Linus Pauling. The Vancouver Premier of the film "Masks of Madness; Science of Healing" featuring Miss Margot Kidder was wonderfully well received by a full house. I followed with a discussion again pointing out that schizophrenic patients on tranquilizer medication alone seldom pay income tax; they do not and can not become normal.
Andrew W. Saul
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