Humphry Osmond, MD: Journal Articles and Books

H. Osmond, M.D. 


Bibliography of Humphry Osmond, M.D.
Edited by Andrew W. Saul, Ph.D. 
(From sources including The National Library of Medicine/Medline, The Library of Congress, Dr. Robert Sommer, and Dr. Abram Hoffer.) 

Dr. Humphry Osmondís remarkable medical career included decades of distinguished psychiatric practice and a prodigious output of writing and research.  He is widely recognized as a pioneer investigator into the chemistry of consciousness.  Along with Dr. John Smythies, Dr. Osmond developed the theory that schizophrenics suffer due to endogenous production of an adrenalin-based hallucinogen. This led to the Hoffer-Osmond Adrenochrome Hypothesis in the early 1950ís, the very origin of orthomolecular medicine. The popular press may today remember Dr. Humphry Osmond for coining the term "psychedelic," but countless thousands of grateful patients will remember him as the co-discoverer of niacin therapy for schizophrenia. This may be the first published comprehensive bibliography of Dr Osmondís work. Additions and corrections are invited. 


Hoffer, Abram & Osmond, Humphry (1952) Paper to Dementia Praecox Committee, Scottish Rites Masons, New York. Given at the Canada Room, The Waldorf Astoria, New York. (Hoffer and Osmondís first report on the adrenochrome hypothesis.) 

Osmond, H & Smythies, J (1952) Schizophrenia: a new approach. Journal of Mental Science. 98(411):309-315, April. 

Osmond, H (1952) On being mad. Saskatchewan Psychiatric Services Journal. Vol 1, No 2. September. 

Hoffer A, Osmond H & Smythies J (1954) Schizophrenia: a new approach. II. Results of a year's research.  J Ment Science 100(418):29-45. 

Clancy J, Hoffer A, Lucy J, Osmond H, Smythies J & Stefaniak B (1954) Design and planning in psychiatric research as illustrated by the Weyburn Chronic Nucleotide Project. Bull Men Clinic, 18: 147-153.

Hoffer A & Osmond H (1955) Schizophrenia - an autonomic disease.  Presented to Soc Biol Psychiatry, Chicago, June. J Nerv & Ment Dis 122: 448-452. 

Hoffer A, Osmond H, Callbeck MJ & Kahan I (1957) Treatment of schizophrenia with nicotinic acid and nicotinamide. J Clin Exper Psychopathol 18: 131-158. 

Osmond H. (1957) A review of the clinical effects of psychotomimetic Agents. Ann N.Y. Acad Sci, 66:418-434. March 14. 

Osmond H. (1957) Function as the basis of psychiatric ward design. Mental Hospitals, 8, 23-29.

Osmond H. (1959) The relationship between architect and psychiatrist. in C. Goshen, (Ed.). Psychiatric Architecture. Wash, DC: American Psychiatric Association.

Osmond H & Hoffer A (1958) The case of Mr. Kovish. J Ment Science 104: 302-325. 

Hoffer A & Osmond H (1959) The adrenochrome model and schizophrenia. J Nerv Mental Dis 128: 18-35. 

Osmond H & Hoffer A (1959) Schizophrenia: a new approach III.  J Ment Science 105: 653-673. 

Osmond H & Hoffer A (1959) On critics and research. Psychosomatic Med 21: 311-320. 

Osmond H & Hoffer A (1959) A small research in Saskatchewan. Can Med Ass J 80: 91-94. 

Hoffer A & Osmond H (1959) Concerning an etiological factor in alcoholism.  The possible role of adrenochrome metabolism.  Quart J Stud Alcohol 20: 750-756. 

Hoffer A & Osmond H (1960) Alcoholism and the researcher. AA Grapevine. 

Sommer R and Osmond H. (1960) Autobiographies of former mental patients. Journal of Mental Science 107:648-662.

Sommer R., Dewar R and Osmond H. (1960) Is there a schizophrenic language? Archives of General Psychiatry 3:665-673.

Sommer R and Osmond H. (1960) Association methods in anthropology. American Anthropologist 62:1051-1053.

Hoffer A & Osmond H (1961) Double blind clinical trials. J Neuropath 2: 221-227. 

Hoffer A & Osmond H (1961) A card sorting test helpful in making psychiatric diagnosis. J Neuropsychiatry 2: 306-330. 

Hoffer A & Osmond H (1961) The biochemistry of mental disease. Can Med Ass J 85: 1309-1311. 

Hoffer A & Osmond H (1961) The relationship between an unknown factor (US) in the urine of subjects and HOD test results.  J Neuropsychiatry 2: 363-368. 

Osmond H & Hoffer A (1961) A brief account of the Saskatchewan research in psychiatry.  J Neuropsychiatry 2: 287-291. 

Sommer, R. and H. Osmond. (1961) Symptoms of institutional care. Social Problems 8:254-263.

Sommer, R., Osmond, H. & Pancyr, L. (1961) Selection of twins for ESP experimentation. International Journal of Parapsychology, Autumn, 55-73.

Sommer, R. and H. Osmond. (1961) Autobiographies of mental patients: Addendum. Journal of Mental Science 107:1030-1032.

Hoffer A & Osmond H (1962) A card sorting test helpful in establishing prognosis. Am J Psychiatry 118: 840-841. 

Hoffer A & Osmond H (1962) Some schizophrenic recoveries.  Dis Nerv Syst 23: 204-210.

Hoffer A & Osmond H (1962) Letter to Editor Re: Double blind clinical trials. J Neuropsychiatry 2: 262-263. 

Hoffer A & Osmond H (1962) Letter to Editor, Adrenaline and schizophrenia. Lancet 1: 643-644. 

Hoffer A & Osmond H (1962) Olfactory changes in schizophrenia. Am J Psychiatry 119: 72-75. 

Hoffer A & Osmond H (1962) Abstraction and schizophrenia.  Can Psych Ass J 7: 186-190. 

Hoffer A & Osmond H (1962) The association between schizophrenia and two objective tests. Can Med Ass J 87: 641-646. 

Hoffer A & Osmond H (1962) The relationship between mood and time perception. Psych Quart 36: 87-92. 

Sommer R and Osmond H (1962) The schizophrenic no-society. Psychiatry 25:244-255.

Sommer R, Witney G and Osmond H. (1962) Teaching common associations to schizophrenics. Journal of Abnormal and Social Psychology 65:58-61.

Osmond H & Hoffer A (1963) Massive niacin treatment in schizophrenia. Review of a nine-year study. Lancet 1: 316-320.

Hoffer A & Osmond H (1963) People are watching me. Psychiatric Quart 37: 7-18. 

Hoffer A & Osmond H (1963) Scurvy and schizophrenia. Dis Nerv Syst 24: 273-285. 

Hoffer A & Osmond H (1963) A comprehensive theory of schizophrenia. Mind 1: 119-121. 

Hoffer A & Osmond H (1963) A question of insight. Dis Nerv Syst 24. 

Hoffer A & Osmond H (1963) Malvaria: a new psychiatric disease. Acta Psychiat Scand 39: 335-366. 

Hoffer A & Osmond H (1963) Some problems of stochastic psychiatry. J Neuropsychiatry 5: 97-11. 

Hoffer A & Osmond H (1964) Treatment of schizophrenia with nicotinic acid - a ten year follow-up. Acta Psychiat Scand 40: 171-189. 

Huxley J, Mayr E, Osmond H & Hoffer A (1964) Schizophrenia as a genetic morphism. Nature, 204: 220-221. 

Huxley J, Mayr E, Osmond H (1965) Schizophrenia. Nature. Jun 2;206(989):1112. 

Osmond H (1965) Commentary on Marsh RP: Meaning and the mind drugs. In Hayakawa SI, (Ed.) A review of general semantics. December. Special Issue on the Psychedelic Experience.

Siegler, Miriam & Osmond, Humphry (1966) Models of madness. Br J Psychiatry. Dec;112(493):1193-203. 

Osmond H (1966) Honor a physician? Some thoughts upon the doctor-patient relationship. J Med Soc N J. 1966 Nov;63(11):512-8. 

Sarett M, Cheek F, Osmond H (1966) Reports of wives of alcoholics of effects of LSD-25 treatment of their husbands. Arch Gen Psychiatry. Feb;14(2):171-8. 

Hoffer A, Osmond H (1966) Some psychological consequences of perceptual disorder and schizophrenia. Int J Neuropsychiatry. Feb;2(1):1-19. 

Osmond H, Hoffer A (1966) A comprehensive theory of schizophrenia. Int J Neuropsychiatry. 1966 Aug;2(4):302-9. Review. 

Hoffer A & Osmond H (1967) A perceptual hypothesis of schizophrenia. Psychiat Digest 28: 47-53. 

Hoffer A & Osmond H (1967) Nicotinamide adenine dinucleotide.  J Psychopharm 1: 79-95. 

Cheek FE, Sarett M, Newell S, Osmond H (1967) A survey of the experience of tension in alcoholics and other diagnostic groups. Int J Neuropsychiatry. Dec;3(6):477-88. 

Hoffer A, Osmond H (1967) A perceptual hypothesis of schizophrenia. Psychiatry Dig. Mar;28(3):47-53. 

Osmond H & Hoffer A (1967) Schizophrenia and suicide. J of Schizophrenia 1: 54-64. 

Kelm H & Hoffer A (1967) Age and the Hoffer-Osmond Diagnostic test. Int J Neuropsychiatry 3: 406-407. 

Kelm H, Callbeck MJ & Hoffer A (1967) A short form of the Hoffer-Osmond Diagnostic test. Int J Neuropsychiatry 3: 489-490. 

Kelm H, Hoffer A & Osmond H (1967) Hoffer-Osmond Diagnostic Manual. Saskatoon.

Siegler M, Osmond H, Newell S (1968) Models of alcoholism. Q J Stud Alcohol. Sep;29(3):571-91. 

Hoffer A, Osmond H (1968) Nicotinamide adenine dinucleotide in the treatment of chronic schizophrenic patients. Br J Psychiatry. Jul;114(512):915-7. 

Siegler M, Cheek FE, Osmond H (1968) Attitudes toward naming the illness. Ment Hyg. Apr;52(2):226-38. 

Mann H, Siegler M, Osmond H (1968) The many worlds of time. J Anal Psychol. Jan;13(1):33-56. 

Osmond H. (1969) How to judge a mental hospital. Schizophrenia, 1 (2). 95-99.

Siegler M, Osmond H, Mann H (1969) Laing's models of madness. Br J Psychiatry. Aug;115(525):947-58. 

Hoffer A & Osmond H (1970) Vitamin B-3 and Krebiozen - a polemic. Schizophrenia 2: 161-165. 

Osmond H (1970) The Seebohm report. Br J Psychiatry. Nov;117(540):607-8. 

Osmond H (1970) The medical model in psychiatry. Hosp Community Psychiatry. Sep;21(9):275-81. 

Siegler M, Osmond H (1971) Goffman's model of mental illness. Br J Psychiatry. Oct;119(551):419-24. 

Osmond H (1971) Philosophical aspects of psychedelics. Int Z Klin Pharmakol Ther Toxikol. Aug;5(1):58-64. 

Osmond H (1972) Learning disability. Can Med Assoc J. Dec 9;107(11):1059. 

Osmond H (1972) The medical model in psychiatry: love it or leave it. Med Ann Dist Columbia. Mar;41(3):171-5. 

Siegler M, Osmond H (1973) The 'sick role' revisited. Stud Hastings Cent. 1(3):41-58. 

Osmond H (1973) The medical and scientific importance of hallucinogens. Practitioner. Jan;210(255):112-9. Review. 

Osmond H (1975) Suicide, medicine and psychoanalysis. Ala J Med Sci. Oct;12(4):394-5. 

Osmond H, Siegler M (1976) The dying role - its clinical importance. Ala J Med Sci. Jul;13(3):313-7. 

Siegler M, Osmond H (1976) The doctor and the dying role. Practitioner. Jun;216(1296):690-4. 

Hoffer A & Osmond H (1976) Megavitamin Therapy. Can Schiz Foundation, Regina. 

Hoffer A & Osmond H (1976) In Reply to The American Psychiatric Association Task Force Report on Megavitamin and Orthomolecular Therapy in Psychiatry. Canadian Schizophrenia Foundation, Regina, Sask., now 16 Florence Ave., Toronto, ON, Canada M2N 1E9, August. 

Osmond H, Siegler M (1977) Doctors as patients. Practitioner. Jun;218 (1308):834-9. 

Osmond, H (1977) Foreword, in Horowitz M. & Palmer C (Ed.) Moksha: Aldous Huxley's Classic Writings on Psychedelics and the Visionary Experience. Park Street Press. (1999 edition: Inner Traditions) 

Osmond H & Hoffer A (1978) Schizophrenia and suicide. J Orthomolecular Psychiatry 7: 57-67. 

Osmond H, Mullaly RW, Bisbee CC. (1978) The medical model and the responsible patient. Hosp Community Psychiatry. Aug;29(8):522-4.

Mullaly RW, Osmond H (1979) Medical education and the dying patient. South Med J. Apr;72(4):409-11.

Hoffer A & Osmond H (1979) Editorial. J Orthomolecular Psychiatry 8: 2-3. 

Hoffer A & Osmond H (1980) Schizophrenia: another long term follow-up in Canada. J Orthomolecular Psychiatry 9: 107-113. 

Osmond H & Hoffer A (1980) Naturally occurring endogenous major and minor tranquilizers. J Orthomolecular Psychiatry 9: 198-206. 

Hoffer A & Osmond H (1980) Book Review. J Orthomolecular Psychiatry 9: 304-306. American Psychiatric Association Task Force Report #14 (Sept 1978) on "Electroconvulsive Therapy," Washington, DC. 

Osmond H. (1980) Model muddle in a student health service: a classic example. Ala J Med Sci. Jul-Oct;17(3-4):342-4. 

Osmond H, Siegler M (1980) The sick role and aesculapian authority. Ala J Med Sci. Apr;17(2):197-201. 

Osmond H (1980) God and the doctor. N Engl J Med. Mar 6;302(10):555-8. 

Hoffer A & Osmond H (1981) Editorial. J Orthomolecular Psychiatry 10:146 only. 

Sommer R and Osmond H. (1981) The mentally ill in the Eighties. Journal of Orthomolecular Psychiatry 10(3):193-201.

Sommer R, Osmond H (1983) A bibliography of mental patients' autobiographies, 1960-1982. Am J Psychiatry. Aug;140(8):1051-4.

Osmond H, Mullaly R, Bisbee C (1984) The pain of depression compared with physical pain. Practitioner. Sep;228(1395):849-53. 

Sommer R, Osmond H (1984) The schizophrenic no-society revisited. Psychiatry. May;47(2):181-91.

Hoffer A & Osmond H (1990) The adrenochrome hypothesis and psychiatry. J Orthomolecular Medicine 5: 32-45. 


Hoffer A & Osmond H (1960) The Chemical Basis of Clinical Psychiatry. C.C. Thomas, Springfield, IL. LOC Control Number: 60009314.

Hoffer A & Osmond H (1966) How To Live With Schizophrenia. University Books, New Hyde Park, NY. LOC Control Number: 66013609. Reprinted 1971. Also published by Johnson, London, 1966.  University Books, Secaucus, N.J.: 1974. LOC Control Number: 74080254 ISBN: 0821600044.  Written by Fannie Kahan.  New and Revised Ed.: Citadel Press (Carol Pub. Group), New York, NY, 1992. LOC Control Number: 92235927. ISBN: 0806513829. 

Hoffer A & Osmond H (1967) The Hallucinogens. Academic Press, New York. LOC Control Number: 66030086.

Kelm H, Hoffer A & Osmond H (1967) Hoffer-Osmond Diagnostic Manual. Saskatoon, SK. 

Hoffer A & Osmond H (1968) New Hope For Alcoholics. University Books, New Hyde Park, N.Y. Written by Fannie Kahan. LOC Control Number: 68018748.

Osmond, H (1968) Medicine & altered states. [Sound recording] Big Sur Recordings. LOC Control Number: 78740297. 1 cassette. 

Aaronson BS & Osmond H, Ed. (1970) Psychedelics: The Uses and Implications of Hallucinogenic Drugs. Garden City, N.Y.: Anchor Books.  LOC Control Number: 70103788. London: Hogarth Press, 1971. LOC Control Number: 71876502. ISBN: 070120348X. Schenkman hardcover edition, 1971. 

El-Meligi, AM & Osmond H (1970) EWI: Manual for the Clinical Use of the Experiential World Inventory. New York: Mens Sana Pub. LOC Control Number: 70139514.

Hoffer A & Osmond H (1970) Comment Vivre Avec la Schizophrenie. Flammarion Editeur, 26 rue Racine, Paris. 

Yaker HM, Osmond H, & Cheek F, Ed. (1971) The Future of Time; Man's Temporal Environment. Garden City, N.Y., Doubleday. LOC Control Number: 79116265. 

Osmond H, Osmundsen JA & Agel J (1973) Understanding Understanding. NY: Harper and Row. LOC Control Number: 72011876.  ISBN: 0060132396. 

Hoffer A & Osmond H (1974) How to Survive with Schizophrenia. University Books, Secaucus, N.J.

Siegler M and Osmond H (1974) Models of Madness, Models of Medicine. Macmillan Pub. Co., New York. LOC Control Number: 74008429. ISBN: 0025940007. Also Collier-Macmillan, London: 1974; Harper Colophon, NY: 1976. 

Hoffer A, Kelm H & Osmond H (1975) The Hoffer-Osmond Diagnostic Test. RE Krieger Pub. Co., Huntington, NY. Also titled, Clinical and Other Uses of the Hoffer-Osmond Diagnostic Test. LOC Control Number: 75020403. ISBN: 0882752944.

Hoffer A & Osmond H (1976) Megavitamin Therapy: In Reply to the American Psychiatric Association Task Force Report on Megavitamins and Orthomolecular Psychiatry. Regina, Sask.: Canadian Schizophrenia Foundation. (Related Title: Megavitamin and orthomolecular therapy in psychiatry.) LOC Control Number: 84246942.

Siegler M & Osmond H (1979) Patienthood: The Art of Being a Responsible Patient. Macmillan, Pub. Co., New York. LOC Control Number: 79001156. ISBN: 0026106701.

Osmond H and Agel J (1981) Predicting the Past: Memos on the Enticing Universe of Possibility. New York: Macmillan. London: Collier Macmillan. LOC Control Number: 81012363. ISBN: 0025940201. 

Siegler, M & Osmond H (1981) How to Cope with Illness. New York: Collier Books. Previously published as: Patienthood. LOC Control Number: 81003910.

Andrew Saul, PhD


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